Wiki’s Hyperinsulinemia Part 2

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I decided to have a look at the article on hyperinsulinemia on Wiki, to see how reliable a resource this is on the condition, although my expectations were on the low side prior to reading it.  I’m actually reading this for the first time as I write this, and we didn’t get beyond the first line in the first article on this, so now we’ll go into the article a little deeper.

The second sentence of the Wiki article asserts that hyperinsulinemia can result from a “variety of metabolic diseases and conditions.”  I wonder why they think that, as it is indeed associated with a variety of diseases and conditions, although it’s shown to cause them, not the other way around.

Later on, they admit that it is unclear to them whether, for instance, obesity causes hyperinsulinemia or hyperinsulinemia causes diabetes, and this shows a total lack of familiarity with the science here, so the statement should have read, it’s associated with a lot of other conditions and we haven’t bothered to look into what causes what so we’re just going to say that these other conditions cause hyperinsulinemia, for the hell of it, just so we can look like we know what we’re talking about.

I don’t want to get into these things too much in this particular set of articles though, as the series would go on for a very long time, and I rather deal and will be dealing with specific manifestations of hyperinsulinemia in other articles that specifically address them.  However it’s interesting how they can arrive at such a conclusion by just proclaiming it like this.

The next line gets even bolder.  It states that although hyperinsulinemia is present in the early stages leading to diabetes, it does not cause it.  Now we don’t just want to claim that when two things occur together, one causes the other, without any evidence, like they just did in the previous sentence, I wonder what evidence they have to support the view that hyperinsulinemia does not cause type 2 diabetes.

Dr. Roger Unger proved that it does cause it, over 50 years ago actually, and whoever wrote this just isn’t familiar at all with Dr. Unger’s research or all the research that has occurred on this topic since.  This position in the article is not only careless but ignorant.  I would have loved to read why they think this doesn’t cause diabetes, but I guess their just proclaiming this and expecting us to believe them is seen as sufficient.

So already I’m thinking, well they have no idea really about the role hyperinsulinemia plays in diabetes or other metabolic diseases, and it’s not that any of this is in any doubt actually.  We understand how this all works, and we can produce diabetes very easily in a clinical setting, as well as the other metabolic disturbances that hyperinsulinemia causes, we just increase insulin levels enough over time.   It doesn’t get clearer than that.

It mentions that there are several causes of hyperinsulinemia, and mentions some minor ones, such as congenital hyperinsulinemia, but it fails to mention what is by far the most common cause, which is cellular toxicity.  You have to be a little familiar with the science here though to know that.

Instead, the theory that is proposed is that the cells become resistant to insulin and therefore this causes the beta cells to secrete more insulin.  This is seen by some as a chicken and egg problem, and they often just go with the egg like they are doing in this article, the insulin resistance causing the higher insulin levels.

There is indeed a feedback loop involved here, but we do know that the majority of this is not caused by the resistance, and it can’t be, because why is it resisting?  You don’t get hormonal resistance from a normal amount of hormone.  There’s only one reason why cells resist insulin, and it’s that they have been exposed to toxic levels of nutrients, driven by insulin.

Now it’s true that the excessive consumption of nutrients does influence this, the carb crazed diets we eat, but without an excess of insulin, the cells don’t get poisoned.  So you need too much insulin first for this to even be possible, for them to have a reason to resist the excess nutrients.

Normal levels of insulin produce normal levels of uptake, and the reason why insulin levels go up after meals is that this is required, if you want more uptake, to metabolize excessive intake, you need more insulin.  When, and only if, this uptake becomes excessive such that the cells become damaged, you get a resistance to this, insulin resistance.

Now the pancreas does fight back and produce more insulin to fight against this resistance, and there’s your feedback loop, but this cannot happen without the condition of hyperinsulinemia producing the resistance in the first place, so there should be no uncertainty at all as far as which comes first, where the real problem lies.

The article claims that since hyperinsulinemia and other metabolic conditions are associated, they occur together, then they must have a common cause.  How can they completely miss the possibility that the hyperinsulinemia is the cause itself here?  At the very least, even in their state of ignorance, they should be saying, it’s possible that hyperinsulinemia could cause these other conditions, the hyperglycemia, the diabetes, the hyperlipidemia, the hypertension, the obesity, the cardiovascular disease, and so on, but they just say, they are all caused by something else, “related or common methods of pathogenicity,.”

The article at least mentions that hyperinsulinemia causes hypertension, so they have at least a little familiar with this, although the explanation given, that it increases sodium retention, is insufficient.  Insulin does this by way of several mechanisms, a pretty long list actually, as hyperinsulinemia messes up a lot of things, but as far as hypertension goes, the main effect is from elevating several hormones that regulate blood pressure.

This just shows that the author just read this comment somewhere and didn’t actually look into the matter very deeply, which is characteristic of the entire article actually.

The article makes the quite humorous remark that hyperinsulinemia “might” worsen insulin resistance, which is a lot like saying drinking too much alcohol “might” make you drunk, or too much poison “might” poison you.  The mechanism by which hyperinsulinemia worsens insulin resistance is as clear as you can get, it’s the insulin that’s being resisted after all, so more will be resisted more.

A big problem when you see discussions of hyperinsulinemia and insulin resistance is that the commentators rarely understand what insulin resistance is, even at its most basic levels, the level where insulin resistance is resisting insulin.  When you start getting into more complicated matters such as why our cells resist this, they tend to become more lost, even thinking that the insulin resistance itself is the problem or the whole problem.

We’ve got more to discuss here which we’ll pick up in Part 3.

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