I'm up to over 150 pages on this site so far, and many more will be added over time, but the most viewed article by a good amount has been the one I've written on the use of berberine in treating type 2 diabetes. So this article is a sort of by popular demand one, and I did say I'd have more to say about this later, and now seems to be a good time to do another one.
I referenced an article in the last one, by Dr. Jonathan Wright, who is certainly one of the brightest and most open minded MDs out there, a credit to his profession to be sure. I show little mercy for this profession and feel that this wrath is more than warranted but there are some, and more all the time, who are escaping the bondage of the mind control experiment that has been so successfully leashed upon them and looking outward toward the world and getting at least a good idea of the sham that their fellows are party to.
Anyway, let's start by sharing another link on berberine, and this one does sum things up pretty well, at least as far as giving people a good and simple idea of the benefits of berberine.
I don't want to talk too much about the basics here, people can read the first article by clicking here, but this current article does summarize some of the benefits quite well. In the study cited, A1C was reduced by 2%, an amazing amount that is actually superior to medications, fasting blood glucose dropped about 70 mg/dl, after meal glucose dropped by over 150 mg/dl, and triglycerides dropped by 20%, and total cholesterol and LDL also both dropped very significantly.
Most notably, in my mind, fasting insulin dropped by 28.1%. So wait a minute, it reduced blood sugar and lowered insulin at the same time? That's the opposite of what medications seek to do generally, and the opposite of what they say we need, don't we need more insulin?
So berberine is lowering blood sugar, but it's doing it by actually reducing insulin resistance. Insulin resistance, as measured by HOMA, was reduced by 44.7%. So in other words, we as diabetics are known to not be sensitive enough to insulin, and this makes us more sensitive to it, and our blood sugar benefits that way.
This is by the way exactly what we need to do in order to treat diabetes properly. In fact it's what's needed if we're to treat type 2 diabetes at all. Type 2 diabetes is in fact insulin resistance, so this is what we need to be looking at in measuring our progress with it. Berberine aces this, other treatments generally make insulin resistance worse, especially insulin or things that increase our natural production of it.
That's the very last thing we need to be doing with insulin resistance though. The whole story here comes down to the reduction in insulin though, the rest of this stuff flows from that. Less excess insulin in particular is marked by better lipid levels, insulin is the devil himself when it comes to high lipid levels.
So less excess insulin and more insulin sensitivity equals less excess glucose production by the liver, pure and simple. This leads to better blood sugar. This involves working with the body to try to fix the problem instead of fighting against it. You can measure this just by looking at insulin resistance. Less insulin resistance is better, more is worse, regardless of one's blood sugar at the present time.
Increasing insulin resistance will make our diabetes worse over time, and decreasing it will improve diabetes over time, it's that simple. Something that improves insulin resistance, like berberine, is to be sought out, things that make it worse needs to be shunned. This is the only real valid measure of one's progress.
We don't care about measuring insulin resistance though, apart from doing so in experiments like this. It's simple to measure though, it's merely the ratio of insulin in the blood to glucose in the blood. We measure our blood glucose all the time, but we rarely measure insulin levels, because that would tell a tale that big pharma doesn't want us to hear, the fact that their treatments are clearly making our diabetes worse over time.
How berberine affects these positive changes isn't all that clear, but there are several. The biggest by far is its effect on increasing AMPK which is a signal that gets broken in diabetes that is responsible for a lot of the excess glucose that we get. Diabetes is a disease of too much endogenous glucose actually, it isn't that we can't handle a normal diet, it's that a normal diet plus all this extra glucose, primarily from the liver, is way too much for anyone to handle.
There's lots of other things that berberine has been shown to effect positively, some things clearly related to blood sugar regulation, some that may play a role in it, and some that have little or nothing to do with diabetes but are still things we should be seeking to improve.
In the end, it doesn't really matter why berberine works, only that it does. Of course, unless your doctor is Jonathan Wright or one of the few forward thinking ones out there, you won't be prescribed berberine, and it's actually a herbally derived preparation that is sold in health food and supplement stores and online without the need for a prescription.
One of the funniest things I've ever encountered is the view some people have that if this stuff worked, their doctor would be giving it to them, or everyone would be taking it, and since this isn't the case, surely it can't work. This is so funny and sad at the same time.
Berberine is far from a cure for type 2 diabetes, but it's something that has been shown to help quite a bit, and help here doesn't mean just lowering blood sugar, it means lowering what's really what's wrong with us, insulin resistance.
Berberine actually satisfies what is supposed to be the first principle of medicine, first do no harm, in other words not making our insulin resistance worse. The second principle needs to be, let's do some good, and berberine, in its improving our condition, does just that. These are the things we need to be focusing on in seeking to improve diabetes, actually looking to improve diabetes, the disease itself.