Diabetes involves the dysregulation of several hormones, the most noteworthy being the pancreatic hormones insulin and glucagon, but there are several others that play a significant role, and adiponectin is definitely on this list. Adiponectin isn’t a hormone that is often mentioned in the discussion of diabetes, but we do know quite a bit about this, it just doesn’t come up much, although it definitely should.
Adiponectin is secreted exclusively by the adipose tissue, fat tissue in other words, and the higher levels of adiponectin you have, the less fat you have. It plays a major role in both glucose and fat metabolism. When levels are low, this results in such things as obesity, particularly excess visceral fat, fatty liver, and type 2 diabetes, and all of these conditions also tend to go together.
Adiponectin levels are inversely correlated with caloric intake, and body fat,, so it’s not hard to see how these conditions have risen dramatically as we eat more and more and see our weight go up more and more in recent years.
One of the benefits of either fasting or reducing caloric intake is that it elevates adiponectin levels, and this can often be quite beneficial in treating diabetes in particular over time. Adiponectin influences glucose levels both directly and indirectly, directly though mechanism such as reducing gluconeogenesis, liver glucose dumping in other words, and indirectly by promoting lipolysis, fat burning, especially visceral fat and fatty organs, and fatty liver and fatty pancreas play a big role in glucose dysregulation and hyperglycemia.
So you might be thinking, well this sounds like a very big deal, and it truly is. This is the stuff we need to be focusing on, taking us away from just looking to reduce blood sugar and looking more toward what is behind all of it, the causes of the high blood sugar, which by the way isn’t because we have a deficiency of certain pharmaceuticals or that we are hyperinsulinemic and require being even more hyperinsulinemic.
Of course we know that this sort of thing, looking to ram the extra sugar into our blood with things like extra insulin, only makes this worse, as this causes excess fat and obesity, and given that this is to a large degree responsible for our condition, we just end up making things worse over time.
Low adiponectin has also shown to play a big role in insulin resistance, and insulin resistance in mice has been completely reversed in mice with a combination of adiponectin and leptin, another hormone that’s quite related to diabetes, and one we’ll be talking about as well in future articles.
Adiponectin even exerts positive effects upon the brain that leads to better metabolism and better weight control, and the brain, particularly the hypothalamus, plays a pretty big role in all of this, as it does with blood sugar control as well, and in fact the hypothalamus will elevate blood sugar if the signaling that it receives tells it that this is needed, and often times it may already be high, but if it doesn’t get the right signals, if this signaling is broken, it will think we’re low and secrete hormones to bring us even higher.
Adiponectin has a host of beneficial effects if its levels are healthy, and many of these are of particular interest to diabetics, such as reduced liver dumping, which is a huge deal with us, increased glucose uptake, better insulin sensitivity and less insulin resistance, better energy metabolism, lower triglycerides, a healthier cardiovascular system, weight loss, and more.
So given that we know that adiponectin levels are too low in type 2 diabetics, and that the effects of being too low are pretty significant indeed, this is something that we really need to be paying a lot of attention to.
One of the features of increasing adiponectin is that since it does reduce body fat and especially visceral fat, it does increase lipolysis, fat burning, and that only stands to reason. However, increasing fat burning does elevate blood sugar levels and can do so pretty significantly. So other than looking to introduce you to this hormone, I also want to point out that it can be pretty confusing to look to elevate this because it often will seem that you are getting worse, and this is the case whenever you look to burn fat.
Fat does play a big role in insulin resistance, and that’s actually an understatement, so when you elevate free fatty acid levels in the blood, which happens when you burn fat, then your blood sugar very often will get worse. Even though we know that this is clearly the case, in other words we have the science telling us this will happen, you don’t really see this effect being talked about when it comes to treating diabetes, mostly because our approach is so simple minded, just do whatever to bring down blood sugar and anything that doesn’t do that, well it’s not for us.
This is not the case at all though, and especially if we are looking to reduce organ fat, this fat has kept our blood sugar high but it has to go, and when it does, well it’s going to smack us real good on the way out the door, and the way out the door can actually take quite a while.
So in other words we are suffering from too high levels of free fatty acids in our blood to start with, and this is to a large degree due to being too fat, and then when we look to lose the fat we’re going to be increasing them even more for a time, and since excess free fatty acids cause insulin resistance, we may see even more while we look to get rid of this excess fat.
So what can we do to increase adiponectin? Well eating less helps, but there are a couple of supplements that do increase this in a meaningful way, which are African mango and raspberry ketones. The raspberry ketones in particular aren’t for the faint of heart though, as in addition to increasing adiponectin, this also elevates adrenal hormones, and when you’re not used to taking it the effects of this will be larger until you adapt, much like caffeine is if you aren’t accustomed to it.
However this stuff does burn fat and a lot of the effect of this is from adiponectin, they can definitely increase your blood sugar at first though, especially raspberry ketones, and in fact with this one a lot of diabetics try it, go up, and then decide it makes them worse, but as I’ve been saying, you never want to be so short sighted, and getting rid of excess fat is what we want to be focusing on here, which is always a good thing, especially for diabetics.